DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes

A genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI), a measure of body fat distribution, associates with increased risk for type 2 diabetes. We conducted an exome-wide association study of coding variation in UK Biobank (405,569 individuals) to identify variants that l...

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Bibliographic Details
Published in:Diabetes
Main Authors: Emdin, Connor A., Khera, Amit V., Aragam, Krishna, Haas, Mary, Chaffin, Mark, Klarin, Derek, Natarajan, Pradeep, Bick, Alexander, Zekavat, Seyedeh M., Nomura, Akihiro, Ardissino, Diego, Wilson, James G., Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J., Samani, Nilesh J., Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Saleheen, Danish, Gabriel, Stacey, Kathiresan, Sekar
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2019
Subjects:
Genetics/Genomes/Proteomics/Metabolomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302541/
https://ncbi.nlm.nih.gov/pubmed/30389748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0857
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