DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes

A genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI), a measure of body fat distribution, associates with increased risk for type 2 diabetes. We conducted an exome-wide association study of coding variation in UK Biobank (405,569 individuals) to identify variants that l...

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Bibliografiske detaljer
Udgivet i:Diabetes
Main Authors: Emdin, Connor A., Khera, Amit V., Aragam, Krishna, Haas, Mary, Chaffin, Mark, Klarin, Derek, Natarajan, Pradeep, Bick, Alexander, Zekavat, Seyedeh M., Nomura, Akihiro, Ardissino, Diego, Wilson, James G., Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J., Samani, Nilesh J., Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Saleheen, Danish, Gabriel, Stacey, Kathiresan, Sekar
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2019
Fag:
Genetics/Genomes/Proteomics/Metabolomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302541/
https://ncbi.nlm.nih.gov/pubmed/30389748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0857
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