ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

BACKGROUND: Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether ANGPTL3 deficiency reduces risk of coronary artery disease (CAD) is unknow...

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Publicado no:J Am Coll Cardiol
Main Authors: Stitziel, Nathan O., Khera, Amit V., Wang, Xiao, Bierhals, Andrew J., Vourakis, A. Christina, Sperry, Alexandra E., Natarajan, Pradeep, Klarin, Derek, Emdin, Connor A., Zekavat, Seyedeh M., Nomura, Akihiro, Erdmann, Jeanette, Schunkert, Heribert, Samani, Nilesh J., Kraus, William E., Shah, Svati H., Yu, Bing, Boerwinkle, Eric, Rader, Daniel J., Gupta, Namrata, Frossard, Philippe M., Rasheed, Asif, Danesh, John, Lander, Eric S., Gabriel, Stacey, Saleheen, Danish, Musunuru, Kiran, Kathiresan, Sekar
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404817/
https://ncbi.nlm.nih.gov/pubmed/28385496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2017.02.030
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