ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

BACKGROUND: Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether ANGPTL3 deficiency reduces risk of coronary artery disease (CAD) is unknow...

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發表在:J Am Coll Cardiol
Main Authors: Stitziel, Nathan O., Khera, Amit V., Wang, Xiao, Bierhals, Andrew J., Vourakis, A. Christina, Sperry, Alexandra E., Natarajan, Pradeep, Klarin, Derek, Emdin, Connor A., Zekavat, Seyedeh M., Nomura, Akihiro, Erdmann, Jeanette, Schunkert, Heribert, Samani, Nilesh J., Kraus, William E., Shah, Svati H., Yu, Bing, Boerwinkle, Eric, Rader, Daniel J., Gupta, Namrata, Frossard, Philippe M., Rasheed, Asif, Danesh, John, Lander, Eric S., Gabriel, Stacey, Saleheen, Danish, Musunuru, Kiran, Kathiresan, Sekar
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404817/
https://ncbi.nlm.nih.gov/pubmed/28385496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2017.02.030
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