ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

BACKGROUND: Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether ANGPTL3 deficiency reduces risk of coronary artery disease (CAD) is unknow...

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Publicat a:J Am Coll Cardiol
Autors principals: Stitziel, Nathan O., Khera, Amit V., Wang, Xiao, Bierhals, Andrew J., Vourakis, A. Christina, Sperry, Alexandra E., Natarajan, Pradeep, Klarin, Derek, Emdin, Connor A., Zekavat, Seyedeh M., Nomura, Akihiro, Erdmann, Jeanette, Schunkert, Heribert, Samani, Nilesh J., Kraus, William E., Shah, Svati H., Yu, Bing, Boerwinkle, Eric, Rader, Daniel J., Gupta, Namrata, Frossard, Philippe M., Rasheed, Asif, Danesh, John, Lander, Eric S., Gabriel, Stacey, Saleheen, Danish, Musunuru, Kiran, Kathiresan, Sekar
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404817/
https://ncbi.nlm.nih.gov/pubmed/28385496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2017.02.030
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