SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

SQSTM1/p62 (sequestosome 1) selectively targets polyubiquitinated proteins for degradation via macroautophagy and the proteasome. Additionally, SQSTM1 shuttles between the cytoplasmic and nuclear compartments, although its role in the nucleus is relatively unknown. Here, we report that SQSTM1 dynami...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Autophagy
Main Authors: Hewitt, Graeme, Carroll, Bernadette, Sarallah, Rezazadeh, Correia-Melo, Clara, Ogrodnik, Mikołaj, Nelson, Glyn, Otten, Elsje G., Manni, Diego, Antrobus, Robin, Morgan, Brian A., von Zglinicki, Thomas, Jurk, Diana, Seluanov, Andrei, Gorbunova, Vera, Johansen, Terje, Passos, João F., Korolchuk, Viktor I.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Basic Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391493/
https://ncbi.nlm.nih.gov/pubmed/27391408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1210368
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