Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

Cellular homoeostatic pathways such as macroautophagy (hereinafter autophagy) are regulated by basic mechanisms that are conserved throughout the eukaryotic kingdom. However, it remains poorly understood how these mechanisms further evolved in higher organisms. Here we describe a modification in the...

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Publicado no:Nat Commun
Main Authors: Carroll, Bernadette, Otten, Elsje G., Manni, Diego, Stefanatos, Rhoda, Menzies, Fiona M., Smith, Graham R., Jurk, Diana, Kenneth, Niall, Wilkinson, Simon, Passos, Joao F., Attems, Johannes, Veal, Elizabeth A., Teyssou, Elisa, Seilhean, Danielle, Millecamps, Stéphanie, Eskelinen, Eeva-Liisa, Bronowska, Agnieszka K., Rubinsztein, David C., Sanz, Alberto, Korolchuk, Viktor I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772351/
https://ncbi.nlm.nih.gov/pubmed/29343728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02746-z
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