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p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control

Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activa...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Eskelinen, Eeva-Liisa, Kageyama, Shun, Komatsu, Masaaki
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018406/
https://ncbi.nlm.nih.gov/pubmed/33855170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2021.1890990
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