Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

p62, also known as sequestosome1 (SQSTM1), A170, or ZIP, is a multifunctional protein implicated in several signal transduction pathways. p62 is induced by various forms of cellular stress, is degraded by autophagy, and acts as a cargo receptor for autophagic degradation of ubiquitinated targets. It...

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Bibliographic Details
Main Authors: Pankiv, Serhiy, Lamark, Trond, Bruun, Jack-Ansgar, Øvervatn, Aud, Bjørkøy, Geir, Johansen, Terje
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820819/
https://ncbi.nlm.nih.gov/pubmed/20018885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039925
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