TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1

The tripartite motif (TRIM) proteins constitute a family of ubiquitin E3 ligases involved in a multitude of cellular processes, including protein homeostasis and autophagy. TRIM32 is characterized by six protein–protein interaction domains termed NHL, various point mutations in which are associated...

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Sci
Hauptverfasser: Overå, Katrine Stange, Garcia-Garcia, Juncal, Bhujabal, Zambarlal, Jain, Ashish, Øvervatn, Aud, Larsen, Kenneth Bowitz, Deretic, Vojo, Johansen, Terje, Lamark, Trond, Sjøttem, Eva
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918758/
https://ncbi.nlm.nih.gov/pubmed/31685529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.236596
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