p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic degradation of ubiquitinated targets, is up-regulated by various stressors. Induction of the p62 gene by oxidative stress is mediated by NF-E2-related factor 2 (NRF2) and, at the same time, p62 protein contributes...

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Detalhes bibliográficos
Main Authors: Jain, Ashish, Lamark, Trond, Sjøttem, Eva, Bowitz Larsen, Kenneth, Atesoh Awuh, Jane, Øvervatn, Aud, McMahon, Michael, Hayes, John D., Johansen, Terje
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903417/
https://ncbi.nlm.nih.gov/pubmed/20452972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118976
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