p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic machinery recognizes such aggregates. In this study, we report that polymerization of the polyubiquitin-binding protein p62/SQSTM1 yields protein bodies that either resid...

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Hlavní autoři: Bjørkøy, Geir, Lamark, Trond, Brech, Andreas, Outzen, Heidi, Perander, Maria, Øvervatn, Aud, Stenmark, Harald, Johansen, Terje
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2005
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171557/
https://ncbi.nlm.nih.gov/pubmed/16286508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200507002
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