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Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic

BACKGROUND: Uracil DNA glycosylase (UDG) plays a major role in repair of uracil formed due to deamination of cytosine. UDG in human cells is present in both the nucleus and mitochondrial compartments. Although, UDG's role in the nucleus is well established its role in mitochondria is less clear...

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Bibliographic Details
Main Authors: Kachhap, Sushant, Singh, Keshav K
Format: Artigo
Language:Inglês
Published: BioMed Central 2004
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC538255/
https://ncbi.nlm.nih.gov/pubmed/15574194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-3-32
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