Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase.

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• Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene.
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• Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively.
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• Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
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• Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites.
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• The presence of nuclear and mitochondrial uracil-DNA glycosylase in extracts of human KB cells.
  von: Anderson, C T, et al.
  Veröffentlicht: (1980)