MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer

How MYC reprograms metabolism in primary tumors remains poorly understood. Using integrated gene expression and metabolite profiling, we identify six pathways that are coordinately deregulated in primary MYC‐driven liver tumors: glutathione metabolism; glycine, serine, and threonine metabolism; amin...

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Bibliografiska uppgifter
I publikationen:EMBO Rep
Huvudupphovsmän: Anderton, Brittany, Camarda, Roman, Balakrishnan, Sanjeev, Balakrishnan, Asha, Kohnz, Rebecca A, Lim, Lionel, Evason, Kimberley J, Momcilovic, Olga, Kruttwig, Klaus, Huang, Qiang, Xu, Guowang, Nomura, Daniel K, Goga, Andrei
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2017
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376764/
https://ncbi.nlm.nih.gov/pubmed/28219903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643068
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