MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer

How MYC reprograms metabolism in primary tumors remains poorly understood. Using integrated gene expression and metabolite profiling, we identify six pathways that are coordinately deregulated in primary MYC‐driven liver tumors: glutathione metabolism; glycine, serine, and threonine metabolism; amin...

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Pubblicato in:EMBO Rep
Autori principali: Anderton, Brittany, Camarda, Roman, Balakrishnan, Sanjeev, Balakrishnan, Asha, Kohnz, Rebecca A, Lim, Lionel, Evason, Kimberley J, Momcilovic, Olga, Kruttwig, Klaus, Huang, Qiang, Xu, Guowang, Nomura, Daniel K, Goga, Andrei
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376764/
https://ncbi.nlm.nih.gov/pubmed/28219903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643068
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