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MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer

How MYC reprograms metabolism in primary tumors remains poorly understood. Using integrated gene expression and metabolite profiling, we identify six pathways that are coordinately deregulated in primary MYC‐driven liver tumors: glutathione metabolism; glycine, serine, and threonine metabolism; amin...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Anderton, Brittany, Camarda, Roman, Balakrishnan, Sanjeev, Balakrishnan, Asha, Kohnz, Rebecca A, Lim, Lionel, Evason, Kimberley J, Momcilovic, Olga, Kruttwig, Klaus, Huang, Qiang, Xu, Guowang, Nomura, Daniel K, Goga, Andrei
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376764/
https://ncbi.nlm.nih.gov/pubmed/28219903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643068
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