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MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer
How MYC reprograms metabolism in primary tumors remains poorly understood. Using integrated gene expression and metabolite profiling, we identify six pathways that are coordinately deregulated in primary MYC‐driven liver tumors: glutathione metabolism; glycine, serine, and threonine metabolism; amin...
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Publicado no: | EMBO Rep |
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Main Authors: | , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
John Wiley and Sons Inc.
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5376764/ https://ncbi.nlm.nih.gov/pubmed/28219903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643068 |
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