MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer

How MYC reprograms metabolism in primary tumors remains poorly understood. Using integrated gene expression and metabolite profiling, we identify six pathways that are coordinately deregulated in primary MYC‐driven liver tumors: glutathione metabolism; glycine, serine, and threonine metabolism; amin...

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Bibliografiske detaljer
Udgivet i:EMBO Rep
Main Authors: Anderton, Brittany, Camarda, Roman, Balakrishnan, Sanjeev, Balakrishnan, Asha, Kohnz, Rebecca A, Lim, Lionel, Evason, Kimberley J, Momcilovic, Olga, Kruttwig, Klaus, Huang, Qiang, Xu, Guowang, Nomura, Daniel K, Goga, Andrei
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376764/
https://ncbi.nlm.nih.gov/pubmed/28219903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643068
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