Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

Expression of the oncogenic transcription factor MYC is disproportionately elevated in triple-negative breast cancer (TNBC) compared to estrogen, progesterone and human epidermal growth factor 2 receptor-positive (RP) breast tumors(1,2). We and others have shown that MYC alters metabolism during tum...

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Publicat a:Nat Med
Autors principals: Camarda, Roman, Zhou, Zhou, Kohnz, Rebecca A., Balakrishnan, Sanjeev, Mahieu, Celine, Anderton, Brittany, Eyob, Henok, Kajimura, Shingo, Tward, Aaron, Krings, Gregor, Nomura, Daniel K., Goga, Andrei
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892846/
https://ncbi.nlm.nih.gov/pubmed/26950360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4055
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