PIM kinase inhibition presents a novel targeted therapy against triple-negative breast tumors with elevated MYC expression

Triple-negative breast cancer (TNBC), which lacks the expression of the estrogen, progesterone, and HER2 receptors, represents the breast cancer subtype with the poorest outcome(1). No targeted therapy is available against this subtype due to lack of validated molecular targets. We previously report...

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Udgivet i:Nat Med
Main Authors: Horiuchi, Dai, Camarda, Roman, Zhou, Alicia Y., Yau, Christina, Momcilovic, Olga, Balakrishnan, Sanjeev, Corella, Alexandra N., Eyob, Henok, Kessenbrock, Kai, Lawson, Devon A., Marsh, Lindsey A., Anderton, Brittany N., Rohrberg, Julia, Kunder, Ratika, Bazarov, Alexey V., Yaswen, Paul, McManus, Michael T., Rugo, Hope S., Werb, Zena, Goga, Andrei
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341692/
https://ncbi.nlm.nih.gov/pubmed/27775705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4213
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