PIM kinase inhibition presents a novel targeted therapy against triple-negative breast tumors with elevated MYC expression

Triple-negative breast cancer (TNBC), which lacks the expression of the estrogen, progesterone, and HER2 receptors, represents the breast cancer subtype with the poorest outcome(1). No targeted therapy is available against this subtype due to lack of validated molecular targets. We previously report...

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Publicado no:Nat Med
Main Authors: Horiuchi, Dai, Camarda, Roman, Zhou, Alicia Y., Yau, Christina, Momcilovic, Olga, Balakrishnan, Sanjeev, Corella, Alexandra N., Eyob, Henok, Kessenbrock, Kai, Lawson, Devon A., Marsh, Lindsey A., Anderton, Brittany N., Rohrberg, Julia, Kunder, Ratika, Bazarov, Alexey V., Yaswen, Paul, McManus, Michael T., Rugo, Hope S., Werb, Zena, Goga, Andrei
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341692/
https://ncbi.nlm.nih.gov/pubmed/27775705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4213
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