A machine learning model to determine the accuracy of variant calls in capture-based next generation sequencing

by van den Akker, Jeroen, Mishne, Gilad, Zimmer, Anjali D., Zhou, Alicia Y.
Published in BMC Genomics (2018)

IκB Kinase ε Phosphorylates TRAF2 To Promote Mammary Epithelial Cell Transformation

by Shen, Rhine R., Zhou, Alicia Y., Kim, Eejung, Lim, Elgene, Habelhah, Hasem, Hahn, William C.
Published 2012

Cancer cells exploit an orphan RNA to drive metastatic progression

by Fish, Lisa, Zhang, Steven, Yu, Johnny, Culbertson, Bruce, Zhou, Alicia Y, Goga, Andrei, Goodarzi, Hani
Published in Nat Med (2018)

Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores

by Homburger, Julian R., Neben, Cynthia L., Mishne, Gilad, Zhou, Alicia Y., Kathiresan, Sekar, Khera, Amit V.
Published in Genome Med (2019)

Cascade Genetic Testing of Relatives for Hereditary Cancer Risk: Results of an Online Initiative

by Caswell-Jin, Jennifer L, Zimmer, Anjali D, Stedden, Will, Kingham, Kerry E, Zhou, Alicia Y, Kurian, Allison W
Published in J Natl Cancer Inst (2018)

TRAF2 is an NF-κB activating oncogene in epithelial cancers

by Shen, Rhine R., Zhou, Alicia Y., Kim, Eejung, O’Connell, Joyce T., Hagerstrand, Daniel, Beroukhim, Rameen, Hahn, William C.
Published 2013

A scalable, aggregated genotypic–phenotypic database for human disease variation

by Barrett, Ryan, Neben, Cynthia L, Zimmer, Anjali D, Mishne, Gilad, McKennon, Wendy, Zhou, Alicia Y, Ginsberg, Jeremy
Published in Database (Oxford) (2019)

IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex

by Zhou, Alicia Y., Shen, Rhine R., Kim, Eejung, Lock, Ying J., Xu, Ming, Chen, Zhijian J., Hahn, William C.
Published 2013

Cancer Recurrence Monitoring using Hyperpolarized [1-(13)C]Pyruvate Metabolic Imaging in Murine Breast Cancer Model

by Shin, Peter J., Zhu, Zihan, Camarda, Roman, Bok, Robert A., Zhou, Alicia Y., Kurhanewicz, John, Goga, Andrei, Vigneron, Daniel B.
Published in Magn Reson Imaging (2017)

Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors

by Caswell, Jennifer L., Camarda, Roman, Zhou, Alicia Y., Huntsman, Scott, Hu, Donglei, Brenner, Steven E., Zaitlen, Noah, Goga, Andrei, Ziv, Elad
Published in Hum Mol Genet (2015)

LEAP: Using machine learning to support variant classification in a clinical setting

by Lai, Carmen, Zimmer, Anjali D., O'Connor, Robert, Kim, Serra, Chan, Ray, van den Akker, Jeroen, Zhou, Alicia Y., Topper, Scott, Mishne, Gilad
Published in Hum Mutat (2020)

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKε promotes cell transformation

by Hutti, Jessica E., Shen, Rhine R., Abbott, Derek W., Zhou, Alicia Y., Sprott, Kam M., Asara, John M., Hahn, William C., Cantley, Lewis C.
Published 2009

Color Data v2: a user-friendly, open-access database with hereditary cancer and hereditary cardiovascular conditions datasets

by Berger, Mark J, Williams, Hannah E, Barrett, Ryan, Zimmer, Anjali D, McKennon, Wendy, Hong, Huy, Ginsberg, Jeremy, Zhou, Alicia Y, Neben, Cynthia L
Published in Database (Oxford) (2020)

Identification of a novel GREM1 duplication in a patient with multiple colon polyps

by McKenna, Danielle B., Van Den Akker, Jeroen, Zhou, Alicia Y., Ryan, Lauren, Leon, Annette, O’Connor, Robert, Shah, Payal D., Rustgi, Anil K., Katona, Bryson W.
Published in Fam Cancer (2019)

Prevalence of Inherited Mutations in Breast Cancer Predisposition Genes among Uganda and Cameroon Women

by Adedokun, Babatunde, Zheng, Yonglan, Ndom, Paul, Gakwaya, Antony, Makumbi, Timothy, Zhou, Alicia Y., Yoshimatsu, Toshio F., Rodriguez, Alex, Madduri, Ravi K., Foster, Ian T., Sallam, Aminah, Olopade, Olufunmilayo I., Huo, Dezheng
Published in Cancer Epidemiol Biomarkers Prev (2019)

Rare TP53 variant associated with Li-Fraumeni syndrome exhibits variable penetrance in a Saudi family

by AlHarbi, Musa, Mubarak, Nahla, AlMubarak, Latifa, Aljelaify, Rasha, AlSaeed, Mariam, Almutairi, Amal, AlJabarat, Weal, Alqubaishi, Fatimah, Al-Subaie, Lamia, AlTassan, Nada, Neben, Cynthia L., Zhou, Alicia Y., Abedalthagafi, Malak
Published in NPJ Genom Med (2018)

The epithelial-mesenchymal transition generates cells with properties of stem cells

by Mani, Sendurai A., Guo, Wenjun, Liao, Mai-Jing, Eaton, Elinor Ng., Ayyanan, Ayyakkannu, Zhou, Alicia Y., Brooks, Mary, Reinhard, Ferenc, Zhang, Cheng Cheng, Shipitsin, Michail, Campbell, Lauren L., Polyak, Kornelia, Brisken, Cathrin, Yang, Jing, Weinberg, Robert A.
Published 2008

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

by Taube, Joseph H., Herschkowitz, Jason I., Komurov, Kakajan, Zhou, Alicia Y., Gupta, Supriya, Yang, Jing, Hartwell, Kimberly, Onder, Tamer T., Gupta, Piyush B., Evans, Kurt W., Hollier, Brett G., Ram, Prahlad T., Lander, Eric S., Rosen, Jeffrey M., Weinberg, Robert A., Mani, Sendurai A.
Published 2010

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

by Fahed, Akl C., Wang, Minxian, Homburger, Julian R., Patel, Aniruddh P., Bick, Alexander G., Neben, Cynthia L., Lai, Carmen, Brockman, Deanna, Philippakis, Anthony, Ellinor, Patrick T., Cassa, Christopher A., Lebo, Matthew, Ng, Kenney, Lander, Eric S., Zhou, Alicia Y., Kathiresan, Sekar, Khera, Amit V.
Published in Nat Commun (2020)

Structure and ubiquitination-dependent activation of Tank-Binding Kinase 1

by Tu, Daqi, Zhu, Zehua, Zhou, Alicia Y., Yun, Cai-hong, Lee, Kyung-Eun, Toms, Angela V., Li, Yiqun, Dunn, Gavin P., Chan, Edmond, Thai, Tran, Yang, Shenghong, Ficarro, Scott B., Marto, Jarrod A., Jeon, Hyesung, Hahn, William C., Barbie, David A., Eck, Michael J.
Published 2013