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Probing Enhanced Double-Strand Break Formation at Abasic Sites within Clustered Lesions in Nucleosome Core Particles
DNA is rapidly cleaved under mild alkaline conditions at apyrimidinic/apurinic sites, but the half-life is several weeks in phosphate buffer (pH 7.5). However, abasic sites are ~100-fold more reactive within nucleosome core particles (NCPs). Histone proteins catalyze the strand scission, and at supe...
Gardado en:
| Publicado en: | Biochemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5372979/ https://ncbi.nlm.nih.gov/pubmed/28005342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01144 |
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