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Rapid DNA–protein cross-linking and strand scission by an abasic site in a nucleosome core particle
Apurinic/apyrimidinic (AP) sites are ubiquitous DNA lesions that are highly mutagenic and cytotoxic if not repaired. In addition, clusters of two or more abasic lesions within one to two turns of DNA, a hallmark of ionizing radiation, are repaired much less efficiently and thus present greater mutag...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012510/ https://ncbi.nlm.nih.gov/pubmed/21149689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012860108 |
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