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Histone Modification via Rapid Cleavage of C4′-Oxidized Abasic Sites in Nucleosome Core Particles

The C4′-oxidized abasic site is produced in DNA by a variety of oxidizing agents, including potent cytotoxic antitumor agents. Independent generation of this alkali-labile lesion at defined positions within nucleosome core particles reveals that the histone proteins increase strand scission between...

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Detalhes bibliográficos
Main Authors: Zhou, Chuanzheng, Sczepanski, Jonathan T., Greenberg, Marc M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638250/
https://ncbi.nlm.nih.gov/pubmed/23531104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400915w
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