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Mechanistic studies on histone catalyzed cleavage of apyrimidinic/apurinic sites in nucleosome core particles
Duplex DNA containing an apurinic/apyrimidinic (AP) lesion undergoes cleavage significantly more rapidly in nucleosome core particles (NCPs) than it does when free. The mechanism of AP cleavage within NCPs was studied through independently generating lesions within them. AP mediated DNA cleavage wit...
Tallennettuna:
| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3477373/ https://ncbi.nlm.nih.gov/pubmed/23020793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja306858m |
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