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Histone catalyzed cleavage of nucleosomal DNA containing 2-deoxyribonolactone
Oxidized abasic sites such as 2-deoxyribonolactone (L) are produced in DNA by a variety of oxidizing agents, including potent cytotoxic antitumor natural products. 2-Deoxyribonolactone is labile to alkaline conditions but its half-life in free DNA at pH 7.5 is approximately one week. Independent gen...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3354019/ https://ncbi.nlm.nih.gov/pubmed/22551239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja302993h |
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