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DNA Damage by Histone Radicals in Nucleosome Core Particles

[Image: see text] Although DNA binding proteins shield the genetic material from diffusible reactive oxygen species by reacting with them, the resulting protein (peroxyl) radicals can oxidize the bound DNA. To explore this possible DNA damage by protein radicals, histone H4 proteins containing an az...

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Autori principali: Zhou, Chuanzheng, Greenberg, Marc M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017609/
https://ncbi.nlm.nih.gov/pubmed/24754228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja501285s
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