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Rapid Histone-Catalyzed DNA Lesion Excision and Accompanying Protein Modification in Nucleosomes and Nucleosome Core Particles
C5′-Hydrogen atoms are frequently abstracted during DNA oxidation. The oxidized abasic lesion 5′-(2-phosphoryl-1,4-dioxobutane) (DOB) is an electrophilic product of the C5′-radical. DOB is a potent irreversible inhibitor of DNA polymerase β, and forms interstrand cross-links in free DNA. We examined...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4612368/ https://ncbi.nlm.nih.gov/pubmed/26290445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05478 |
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