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Rapid Histone-Catalyzed DNA Lesion Excision and Accompanying Protein Modification in Nucleosomes and Nucleosome Core Particles

C5′-Hydrogen atoms are frequently abstracted during DNA oxidation. The oxidized abasic lesion 5′-(2-phosphoryl-1,4-dioxobutane) (DOB) is an electrophilic product of the C5′-radical. DOB is a potent irreversible inhibitor of DNA polymerase β, and forms interstrand cross-links in free DNA. We examined...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Weng, Liwei, Greenberg, Marc M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612368/
https://ncbi.nlm.nih.gov/pubmed/26290445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05478
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