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5-Formylcytosine Yields DNA-Protein Crosslinks in Nucleosome Core Particles
In situ generation of 5-formylcytosine (5fC) in nucleosome core particles (NCPs) reveals that 5fC leads to essential DNA-protein crosslinks (DPCs). Mechanistic studies using chemical models and mutated histones demonstrate that DPCs form reversibly between the formyl function of 5fC and primary amin...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5649621/ https://ncbi.nlm.nih.gov/pubmed/28742335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05495 |
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