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Oxidation of 8-oxo-7,8-dihydro-2’-deoxyguanosine leads to substantial DNA-histone cross-links within nucleosome core particles
8-Oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo) is a common primary product of cellular oxidative DNA damage. 8-OxodGuo is more readily oxidized than 2’-deoxyguanosine (dG); a two-electron oxidation generates a highly reactive intermediate (OG(ox)), which forms covalent adducts with nucleophiles, in...
Gorde:
| Argitaratua izan da: | Chem Res Toxicol |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6425731/ https://ncbi.nlm.nih.gov/pubmed/30412392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00244 |
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