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Enhanced Cleavage at Abasic Sites Within Clustered Lesions in Nucleosome Core Particles
Clustered lesions are a hallmark of γ-radiolysis, and are produced by other damaging agents as well. Bistranded clustered lesions are precursors to double strand breaks and pose challenges to repair, making them an especially deleterious form of DNA damage. An abasic site (AP) is an alkaline-labile...
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| Veröffentlicht in: | Chembiochem |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6172155/ https://ncbi.nlm.nih.gov/pubmed/30043401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800338 |
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