Φορτώνει......
Probing Enhanced Double-Strand Break Formation at Abasic Sites within Clustered Lesions in Nucleosome Core Particles
DNA is rapidly cleaved under mild alkaline conditions at apyrimidinic/apurinic sites, but the half-life is several weeks in phosphate buffer (pH 7.5). However, abasic sites are ~100-fold more reactive within nucleosome core particles (NCPs). Histone proteins catalyze the strand scission, and at supe...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Biochemistry |
|---|---|
| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
|
| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5372979/ https://ncbi.nlm.nih.gov/pubmed/28005342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01144 |
| Ετικέτες: |
Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!
|