Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination

Intrathecal immunoglobulin G (IgG) synthesis, cerebrospinal fluid (CSF) oligoclonal IgG bands and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Both the specific targets and pathogenic effects of MS antibodies remain poorly characterized. We produced IgG1...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Liu, Yiting, Given, Katherine S., Harlow, Danielle E., Matschulat, Adeline M., Macklin, Wendy B., Bennett, Jeffrey L., Owens, Gregory P.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366134/
https://ncbi.nlm.nih.gov/pubmed/28340598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0428-6
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