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Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination
Intrathecal immunoglobulin G (IgG) synthesis, cerebrospinal fluid (CSF) oligoclonal IgG bands and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Both the specific targets and pathogenic effects of MS antibodies remain poorly characterized. We produced IgG1...
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| Veröffentlicht in: | Acta Neuropathol Commun |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5366134/ https://ncbi.nlm.nih.gov/pubmed/28340598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0428-6 |
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