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Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination

Intrathecal immunoglobulin G (IgG) synthesis, cerebrospinal fluid (CSF) oligoclonal IgG bands and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Both the specific targets and pathogenic effects of MS antibodies remain poorly characterized. We produced IgG1...

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Bibliografske podrobnosti
izdano v:	Acta Neuropathol Commun
Main Authors:	Liu, Yiting, Given, Katherine S., Harlow, Danielle E., Matschulat, Adeline M., Macklin, Wendy B., Bennett, Jeffrey L., Owens, Gregory P.
Format:	Artigo
Jezik:	Inglês
Izdano:	BioMed Central 2017
Teme:	Research
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5366134/ https://ncbi.nlm.nih.gov/pubmed/28340598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0428-6
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Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination

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