Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination

Intrathecal immunoglobulin G (IgG) synthesis, cerebrospinal fluid (CSF) oligoclonal IgG bands and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Both the specific targets and pathogenic effects of MS antibodies remain poorly characterized. We produced IgG1...

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Publicado en:Acta Neuropathol Commun
Autores principales: Liu, Yiting, Given, Katherine S., Harlow, Danielle E., Matschulat, Adeline M., Macklin, Wendy B., Bennett, Jeffrey L., Owens, Gregory P.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366134/
https://ncbi.nlm.nih.gov/pubmed/28340598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0428-6
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