Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination

Intrathecal immunoglobulin G (IgG) synthesis, cerebrospinal fluid (CSF) oligoclonal IgG bands and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Both the specific targets and pathogenic effects of MS antibodies remain poorly characterized. We produced IgG1...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Liu, Yiting, Given, Katherine S., Harlow, Danielle E., Matschulat, Adeline M., Macklin, Wendy B., Bennett, Jeffrey L., Owens, Gregory P.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366134/
https://ncbi.nlm.nih.gov/pubmed/28340598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0428-6
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