Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica

BACKGROUND: Studies of neuromyelitis optica (NMO), an autoimmune disease of the central nervous system (CNS), have demonstrated that autoantibodies against the water channel aquaporin-4 (AQP4) induce astrocyte damage through complement-dependent cytotoxicity (CDC). In developing experimental models...

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Publicat a:J Neuroinflammation
Autors principals: Liu, Yiting, Harlow, Danielle E., Given, Katherine S., Owens, Gregory P., Macklin, Wendy B., Bennett, Jeffrey L.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5134246/
https://ncbi.nlm.nih.gov/pubmed/27905992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0767-4
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