Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination

Intrathecal immunoglobulin G (IgG) synthesis, cerebrospinal fluid (CSF) oligoclonal IgG bands and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Both the specific targets and pathogenic effects of MS antibodies remain poorly characterized. We produced IgG1...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Liu, Yiting, Given, Katherine S., Harlow, Danielle E., Matschulat, Adeline M., Macklin, Wendy B., Bennett, Jeffrey L., Owens, Gregory P.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366134/
https://ncbi.nlm.nih.gov/pubmed/28340598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0428-6
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