Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase

Poly(ADP-ribosylation) of proteins following DNA damage is well studied and the use of poly(ADP-ribose) polymerase (PARP) inhibitors as therapeutic agents is an exciting prospect for the treatment of many cancers. Poly(ADP-ribose) glycohydrolase (PARG) has endo- and exoglycosidase activities which c...

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Dettagli Bibliografici
Pubblicato in:DNA Repair (Amst)
Autori principali: Gravells, Polly, Grant, Emma, Smith, Kate M., James, Dominic I., Bryant, Helen E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360195/
https://ncbi.nlm.nih.gov/pubmed/28254358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.02.010
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