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The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase
DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme...
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| 出版年: | Molecules |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6259645/ https://ncbi.nlm.nih.gov/pubmed/21343889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16021854 |
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