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Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins. PARPs are known to function in a large range of cellular processes including DNA repair, DNA replication, transcription and modulati...

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Detalhes bibliográficos
Main Authors: Daniel Harrision, Polly Gravells, Ruth Thompson, Helen E. Bryant
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-08-01
Colecção:Frontiers in Molecular Biosciences
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Acesso em linha:https://www.frontiersin.org/article/10.3389/fmolb.2020.00191/full
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