An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells

After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG). Inhibition of PARG leads to a failure of DNA repair and small molecule inhibition of PARG has been a goal for many ye...

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Detalhes bibliográficos
Publicado no:F1000Res
Main Authors: James, Dominic I., Durant, Stephen, Eckersley, Kay, Fairweather, Emma, Griffiths, Louise A., Hamilton, Nicola, Kelly, Paul, O'Connor, Mark, Shea, Kerry, Waddell, Ian D., Ogilvie, Donald J.
Formato: Artigo
Idioma:Inglês
Publicado em: F1000Research 2016
Assuntos:
Method Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995692/
https://ncbi.nlm.nih.gov/pubmed/27610220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.8463.2
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