Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins. PARPs are known to function in a large range of cellular processes including DNA repair, DNA replication, transcription and modulati...

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Veröffentlicht in:Front Mol Biosci
Hauptverfasser: Harrision, Daniel, Gravells, Polly, Thompson, Ruth, Bryant, Helen E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Molecular Biosciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485115/
https://ncbi.nlm.nih.gov/pubmed/33005627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00191
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