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Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase
Poly(ADP-ribosylation) of proteins following DNA damage is well studied and the use of poly(ADP-ribose) polymerase (PARP) inhibitors as therapeutic agents is an exciting prospect for the treatment of many cancers. Poly(ADP-ribose) glycohydrolase (PARG) has endo- and exoglycosidase activities which c...
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| Publicado no: | DNA Repair (Amst) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5360195/ https://ncbi.nlm.nih.gov/pubmed/28254358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.02.010 |
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