TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth

Infection is the most common cause of mortality in early life, and immunization is the most promising biomedical intervention to reduce this burden. However, newborns fail to respond optimally to most vaccines. Adjuvantation is a key approach to enhancing vaccine immunogenicity, but responses of hum...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Dowling, David J., van Haren, Simon D., Scheid, Annette, Bergelson, Ilana, Kim, Dhohyung, Mancuso, Christy J., Foppen, Willemina, Ozonoff, Al, Fresh, Lynn, Theriot, Terese B., Lackner, Andrew A., Fichorova, Raina N., Smirnov, Dmitri, Vasilakos, John P., Beaurline, Joe M., Tomai, Mark A., Midkiff, Cecily C., Alvarez, Xavier, Blanchard, James L., Gilbert, Margaret H., Aye, Pyone Pyone, Levy, Ofer
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360187/
https://ncbi.nlm.nih.gov/pubmed/28352660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91020
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