TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth

Infection is the most common cause of mortality in early life, and immunization is the most promising biomedical intervention to reduce this burden. However, newborns fail to respond optimally to most vaccines. Adjuvantation is a key approach to enhancing vaccine immunogenicity, but responses of hum...

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Vydáno v:JCI Insight
Hlavní autoři: Dowling, David J., van Haren, Simon D., Scheid, Annette, Bergelson, Ilana, Kim, Dhohyung, Mancuso, Christy J., Foppen, Willemina, Ozonoff, Al, Fresh, Lynn, Theriot, Terese B., Lackner, Andrew A., Fichorova, Raina N., Smirnov, Dmitri, Vasilakos, John P., Beaurline, Joe M., Tomai, Mark A., Midkiff, Cecily C., Alvarez, Xavier, Blanchard, James L., Gilbert, Margaret H., Aye, Pyone Pyone, Levy, Ofer
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360187/
https://ncbi.nlm.nih.gov/pubmed/28352660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91020
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