TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth

Infection is the most common cause of mortality in early life, and immunization is the most promising biomedical intervention to reduce this burden. However, newborns fail to respond optimally to most vaccines. Adjuvantation is a key approach to enhancing vaccine immunogenicity, but responses of hum...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Dowling, David J., van Haren, Simon D., Scheid, Annette, Bergelson, Ilana, Kim, Dhohyung, Mancuso, Christy J., Foppen, Willemina, Ozonoff, Al, Fresh, Lynn, Theriot, Terese B., Lackner, Andrew A., Fichorova, Raina N., Smirnov, Dmitri, Vasilakos, John P., Beaurline, Joe M., Tomai, Mark A., Midkiff, Cecily C., Alvarez, Xavier, Blanchard, James L., Gilbert, Margaret H., Aye, Pyone Pyone, Levy, Ofer
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360187/
https://ncbi.nlm.nih.gov/pubmed/28352660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91020
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