TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth

Infection is the most common cause of mortality in early life, and immunization is the most promising biomedical intervention to reduce this burden. However, newborns fail to respond optimally to most vaccines. Adjuvantation is a key approach to enhancing vaccine immunogenicity, but responses of hum...

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Bibliografski detalji
Izdano u:JCI Insight
Glavni autori: Dowling, David J., van Haren, Simon D., Scheid, Annette, Bergelson, Ilana, Kim, Dhohyung, Mancuso, Christy J., Foppen, Willemina, Ozonoff, Al, Fresh, Lynn, Theriot, Terese B., Lackner, Andrew A., Fichorova, Raina N., Smirnov, Dmitri, Vasilakos, John P., Beaurline, Joe M., Tomai, Mark A., Midkiff, Cecily C., Alvarez, Xavier, Blanchard, James L., Gilbert, Margaret H., Aye, Pyone Pyone, Levy, Ofer
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360187/
https://ncbi.nlm.nih.gov/pubmed/28352660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91020
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