Age-specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1-polarization

Due to functionally distinct cell-mediated immunity, newborns and infants are highly susceptible to infection with intracellular pathogens. Indeed, neonatal antigen-presenting dendritic cells (DCs) demonstrate impaired Th1 responses to many candidate adjuvants, including most TLR agonists (TLRAs). C...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: van Haren, Simon D., Dowling, David J., Foppen, Willemina, Christensen, Dennis, Andersen, Peter, Reed, Steven G., Hershberg, Robert M., Baden, Lindsey R, Levy, Ofer
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386828/
https://ncbi.nlm.nih.gov/pubmed/27793997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600282
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