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Noncanonical NF-κB mediates the Suppressive Effect of Neutrophil Elastase on IL-8/CXCL8 by Inducing NKRF in Human Airway Smooth Muscle

Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective induction of NKRF and dysregulation in chronic inflammatory diseases. We hypothesized that...

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Publicat a:Sci Rep
Autors principals: Ho, Shu-Chuan, Wu, Sheng-Ming, Feng, Po-Hao, Liu, Wen-Te, Chen, Kuan-Yuan, Chuang, Hsiao-Chi, Chan, Yao-Fei, Kuo, Lu-Wei, Lee, Kang-Yun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359717/
https://ncbi.nlm.nih.gov/pubmed/28322300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44930
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