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Noncanonical NF-κB mediates the Suppressive Effect of Neutrophil Elastase on IL-8/CXCL8 by Inducing NKRF in Human Airway Smooth Muscle

Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective induction of NKRF and dysregulation in chronic inflammatory diseases. We hypothesized that...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Ho, Shu-Chuan, Wu, Sheng-Ming, Feng, Po-Hao, Liu, Wen-Te, Chen, Kuan-Yuan, Chuang, Hsiao-Chi, Chan, Yao-Fei, Kuo, Lu-Wei, Lee, Kang-Yun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359717/
https://ncbi.nlm.nih.gov/pubmed/28322300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44930
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