Neutrophil Elastase Increases Airway Epithelial Nonheme Iron Levels

Alpha‐1‐antitrypsin (A1AT) deficiency is characterized by increased neutrophil elastase (NE) activity and oxidative stress in the lung. We hypothesized that NE exposure generates reactive oxygen species by increasing lung nonheme iron. To test this hypothesis, we measured bronchoalveolar lavage (BAL...

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Detaylı Bibliyografya
Asıl Yazarlar: Fischer, Bernard M., Domowicz, Denise A. Lopez, Zheng, Shuo, Carter, Jamie L., McElvaney, N. Gerry, Taggart, Clifford, Lehmann, James R., Voynow, Judith A., Ghio, Andrew J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Inc 2009
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857349/
https://ncbi.nlm.nih.gov/pubmed/20411049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1752-8062.2009.00151.x
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