Neutrophil Elastase Increases Airway Epithelial Nonheme Iron Levels

Alpha‐1‐antitrypsin (A1AT) deficiency is characterized by increased neutrophil elastase (NE) activity and oxidative stress in the lung. We hypothesized that NE exposure generates reactive oxygen species by increasing lung nonheme iron. To test this hypothesis, we measured bronchoalveolar lavage (BAL...

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Hlavní autoři: Fischer, Bernard M., Domowicz, Denise A. Lopez, Zheng, Shuo, Carter, Jamie L., McElvaney, N. Gerry, Taggart, Clifford, Lehmann, James R., Voynow, Judith A., Ghio, Andrew J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Inc 2009
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857349/
https://ncbi.nlm.nih.gov/pubmed/20411049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1752-8062.2009.00151.x
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